Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contraction | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contraction | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 481 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in Wistar rat aorta rings assessed as reduction in L-type Ba(2+) current at Vh of -50 mV | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50280989 (2,6-dimethyl-5-methyloxycarbonyl-4-(3-nitrophenyl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 592 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of [3H]PN-200-110 binding to L-type calcium channels in rat cortex membranes. | Bioorg Med Chem Lett 3: 2099-2104 (1993) Article DOI: 10.1016/S0960-894X(01)81025-8 BindingDB Entry DOI: 10.7270/Q2DV1JS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50080302 (2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of L-type calcium channels in GH-3 rat pituitary cells | Bioorg Med Chem Lett 9: 2447-52 (1999) BindingDB Entry DOI: 10.7270/Q2FB524M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contraction | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50080296 (2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of L-type calcium channels in GH-3 rat pituitary cells | Bioorg Med Chem Lett 9: 2447-52 (1999) BindingDB Entry DOI: 10.7270/Q2FB524M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50085561 (4-[2-(3-{2-[2-(3-Hydroxy-phenyl)-ethyl]-benzyloxy}...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Neuroscience Research Centre Curated by ChEMBL | Assay Description Inhibition of L-type [Ca2+] channel (VSCC) in rat A7r5 vascular smooth muscle cells | Bioorg Med Chem Lett 10: 345-7 (2000) BindingDB Entry DOI: 10.7270/Q2PV6JKZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50080295 (2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of L-type calcium channels in GH-3 rat pituitary cells | Bioorg Med Chem Lett 9: 2447-52 (1999) BindingDB Entry DOI: 10.7270/Q2FB524M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50085560 (4-[2-(3-{2-[2-(4-Hydroxy-phenyl)-ethyl]-benzyloxy}...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Neuroscience Research Centre Curated by ChEMBL | Assay Description Inhibition of L-type [Ca2+] channel (VSCC) in rat A7r5 vascular smooth muscle cells | Bioorg Med Chem Lett 10: 345-7 (2000) BindingDB Entry DOI: 10.7270/Q2PV6JKZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50212319 (CHEMBL18412) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | n/a | n/a | 5.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Displacement of [3H]nitrendipine from calcium channel receptor | Citation and Details BindingDB Entry DOI: 10.7270/Q2F47RB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50080299 (2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of L-type calcium channels in GH-3 rat pituitary cells | Bioorg Med Chem Lett 9: 2447-52 (1999) BindingDB Entry DOI: 10.7270/Q2FB524M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50019968 (7-Ethyl-1,3,5-trimethyl-6,7-dihydro-1H-1,2,4,5a,8-...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Displacement of [3H]nitrendipine from L-type [Ca2+] channel of rat brain | J Med Chem 31: 454-61 (1988) BindingDB Entry DOI: 10.7270/Q25T3JGG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50046397 (CHEMBL3314412) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contraction | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50046397 (CHEMBL3314412) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contraction | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50046397 (CHEMBL3314412) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contraction | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50046397 (CHEMBL3314412) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contraction | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50046399 (CHEMBL3314413) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contraction | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50046399 (CHEMBL3314413) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contraction | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50046399 (CHEMBL3314413) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contraction | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50046399 (CHEMBL3314413) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.26E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contraction | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50046397 (CHEMBL3314412) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.51E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vietnam Academy of Science and Technology Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in Wistar rat aorta rings assessed as reduction in L-type Ba(2+) current at Vh of -50 mV | J Nat Prod 77: 1586-93 (2014) Article DOI: 10.1021/np500076v BindingDB Entry DOI: 10.7270/Q26H4K1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50230150 (CHEMBL345052) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >5.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranes | J Med Chem 35: 4442-9 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4MQB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50001689 (4-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropoxy...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 5.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranes | J Med Chem 35: 4442-9 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4MQB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50230151 (CHEMBL136313) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | >5.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranes | J Med Chem 35: 4442-9 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4MQB | |||||||||||
More data for this Ligand-Target Pair |